Inactivation of Influenza Viruses with Heteropolyacids
نویسندگان
چکیده
The antiviral activity of Keggin heteropolyacids (HPAs) against the human influenza A/California/07/09 (H1N1) pdm09 virus is studied in MDCK cell culture. Transmission electron microscopy reveals new features destruction viral particles by HPAs. A proton-anion model that considers main biochemical processes leading to enveloped viruses: depletion membrane cholesterol HPA anions, acidification M1 matrix protein protons medium, and anion lysis lipid membranes, proposed. Arrhenius dependences biological properties HPAs on temperature are predicted. general mechanism for formation high described, which underlined bilipid a effect biochemistry polyoxometalates.
منابع مشابه
Mechanism of inactivation of influenza viruses by immobilized hydrophobic polycations.
N,N-dodecyl,methyl-polyethylenimine coatings applied to solid surfaces have been shown by us to disinfect aqueous solutions of influenza viruses. Herein we elucidate the mechanism of this phenomenon. Infectivity-, protein-, RNA-, and scanning electron microscopy-based experiments reveal that, upon contact with the hydrophobic polycationic coating, influenza viruses (including pathogenic human a...
متن کاملInactivation of Viruses for Vaccines **
Several attempts have been made to use ionizing radiation as a means of inactivating viruses so that they can be employed as killed vaccines. Success has been achieved with a rabies virus, and trials have also been made with poliomyelitis virus.""7 These methods have not been used for practical purposes, partly because of their novelty, because of the expense in the original setting up of the e...
متن کاملToxicity of Influenza Viruses
I n the preceding paper exper iments were described on the effect of in t racerebral inject ion of influenza virus prepara t ions . Convulsions were no ted in mice within 24 to 7.2 hours and occasionally later , wi thout demonst rable propagat ion of the agents in the central nervous system. I t was concluded tha t the influenza viruses m a y exert toxic effects on an organ which usual ly does ...
متن کاملEffect of ozone on the inactivation of indoor airborne viruses with the COVID-19 virus approach: a systematic review
Background: Nowadays, the COVID-19 pandemic has become a global problem that new methods must be used to prevent it. The virus is highly contagious and is mainly transmitted through the air. Ozone is a powerful oxidant that can be used to inactivate a wide range of viruses that may be resistant to other disinfectants. The purpose of this study was to review the use and effect of ozone in inacti...
متن کاملReproduction of Influenza Viruses
Influenza A and B virus reproduction in the allantoic membrane of the intact chicken embryo was studied quantitatively with particle enumeration procedures. Virus particles were enumerated on the basis of two independent properties; capacity to infect and to cause hemagglutination. The infective property of influenza B virus (Lee) was even more unstable than that of influenza A virus (PR8). Ina...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nanobiotechnology reports
سال: 2022
ISSN: ['2635-1676', '2635-1684']
DOI: https://doi.org/10.1134/s2635167622020070